Growth hormone deficiency in children: Symptoms & treatment

It is concerning when a child continues to grow older without becoming taller. This is initially ignored, but when school uniforms change annually but height does not, parents become alarmed. It is not always late growth or genetics; sometimes it's hormonal. One of the most important hormones that controls a child's growth is growth hormone. It is produced by the pituitary gland in the brain. When a child does not grow enough of it, then the child develops a medical condition that is called growth hormone deficiency (GHD).

Growth hormone deficiency in children: Symptoms & treatment

If this GHD issue is not appropriately managed by a qualified doctor, a child may experience problems with their bones, muscles, metabolism, and self-esteem as they enter adolescence.

In this blog, you can learn about GHD symptoms and treatment.

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What is growth hormone deficiency in children?

Growth hormone deficiency (GHD) happens when the pituitary gland fails to produce sufficient growth hormone needed for normal body development. Growth hormone regulates energy, fat metabolism, organ growth, muscle growth, and bone lengthening (height). After the age of three, children typically grow 5-7 cm annually. Growth is significantly slowed when GHD is present. GHD can be:

  1. Born with it or congenital: The pituitary gland is not fully developed, or hormone production is impacted by genetic issues.
  2. Developed later or acquired: It can be caused by brain injury, brain tumor, infection affecting the brain, radiation therapy, or unknown causes, which is very common.

Growth hormone deficiency symptoms in children

The growth hormone (GH) is mostly released during sleep. For this reason, during childhood and puberty, children undergo significant growth. Without enough GH, the body simply does not get the signal to grow. Normally, the parents often miss this condition at first if the child looks normal. But doctors don't look at appearance; they focus on growth pattern. Some common symptoms of growth hormone deficiency are given below:

  • Very slow height increase: Normally, a child grows 5 to 7 cm per year after age 3, but a child with GHD only grows less than 4 cm per year.
  • Short height compared to parents: If both parents have average height but the child remains unusually short in comparison to them, then it raises suspicion.
  • Younger facial appearances: A child often looks younger than their age, such as having a baby face.
  • Increased body fat: If a child is having increased body fat, especially around the abdomen and chest, then it is a problem.
  • Delayed puberty: Sometimes puberty is delayed. It shows no sign at the expected age.
  • Weak muscles and delayed tooth eruption: Sometimes, teeth appear later than normal. Muscle strength is weaker than that of others.
  • Infant symptoms: Some symptoms in the case of infants are poor feeding habits, low blood sugar, prolonged jaundice, and small genital size in boys.
  • Growth chart data: When a child's growth chart crosses downward percentiles, doctors can tell that the child is not following the typical growth curve.
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The treatments for growth hormone deficiency (GHD) in children

The good news is that GHD is treatable thanks to advances in contemporary medicine. It is best to start treatment early. Late diagnosis is the risk, not medication. because growth plates shut down after puberty, making it impossible to grow taller. GH therapy is safe when it is prescribed properly and monitored by a pediatrician.

Somatropin injection or growth hormone therapy: It is a treatment that involves recombinant human growth hormone, which is the synthetic version identical to the natural hormone. Its work processes are:

  • Once daily, a tiny subcutaneous injection is administered.
  • Usually administered at night because natural GH is released during sleep.
  • Continued for several years until the growth plates close.
  • Every three to six months, doctors check blood hormone levels, bone age, height, and the onset of puberty.
  • When improvement starts, parents typically notice an increase in appetite, better energy, and height acceleration in 3 to 4 months.

Why is early treatment necessary for GHD in children?

Psychologically, children suffer more than physically. A child who is repeatedly treated as younger than their age often develops social anxiety and poor academic performance. In adolescence, this can affect personality formation and long-term mental health, so this condition is not only about height. Untreated growth hormone deficiency, or GHD, can lead to:

  • Bones may not reach full strength.
  • Body composition stays skewed toward fat.
  • Poor muscle mass.
  • Low self-confidence.
  • Metabolic issues can develop.

Get expert treatment for GHD in children!

A specialized evaluation is necessary for a proper diagnosis of GHD. A pediatric endocrinologist has to do it; it's not as simple as speculating based on height. Prof. Dr. Salahuddin Mahmud specializes in identifying and treating growth hormone deficiency in children through individualized treatment plans and evidence-based care.

Prof. Dr. Salahuddin Mahmud an expert treatment for GHD in children!

He is a renowned pediatric specialist in the field of child healthcare in Bangladesh. who is also an expert in pediatric gastroenterology, pediatric hepatology, child nutritional disorders, pediatric liver transplants, child diarrhea treatment, child abdominal migraine treatment, child constipation treatment, and severe acute malnutrition.

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FAQ about growth hormone deficiency in children

Parents should be concerned if a child older than 3 years grows less than about 4–5 cm per year or remains the smallest among classmates for a long time. If the child’s height is far below what would be expected from the parents’ height, a medical evaluation is recommended instead of waiting for puberty.

No. Genetic short height means the child follows a normal growth pattern but stays short like the parents. Growth hormone deficiency is different—the child’s growth rate slows down abnormally and drops on the growth chart. This is a medical condition and requires hormone testing and specialist assessment.

Yes, when prescribed and monitored by a qualified pediatric specialist. Growth hormone therapy (somatropin injection) is a synthetic form identical to the natural hormone. Doctors regularly monitor height, bone age, and hormone levels to ensure safety and effectiveness.

Treatment usually continues for several years, often until puberty is completed and growth plates close. Many parents notice improved appetite, energy, and height increase within about 3–4 months after starting therapy.

Untreated GHD can lead to permanently short adult height, weak bones, higher body fat, reduced muscle mass, delayed puberty, and low self-confidence. After puberty begins, growth plates close, and height cannot be significantly increased, so early diagnosis is very important.

Disclaimer: The information published on this website is provided solely for awareness and educational purposes. It is not intended as a substitute for professional medical advice. Always consult a qualified specialist or physician before making any medical decisions.

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